A serial killer is on the loose in New York City. His victims are middle-aged men, fans of intimate dating through newspaper ads. But, unfortunately, the dates end badly for the romantics: their naked corpses are found with a bullet in the head, in the same position....

Experienced detectives Frank Caller (Al Pacino) and his partner Sherman (John Goodman) are tasked with finding the killer. The cops come up with a brilliant plan. They decide to place their own ad in the newspaper and thus catch the killer "on the live".

On assignment from the Vatican, Jack Crowe, a hereditary vampire hunter, and his friend and partner Montoya ruthlessly slay ghouls, but their main target is a particularly dangerous vampire Valek, a native of Prague, born in the 1300s. Jack and Montoya are aided in their vampire hunt by a young priest armed with knowledge from ancient treatises on bloodsuckers.

Valek searches the States for an ancient crucifix with special powers. Vampires are known to be afraid of sunlight, which kills them. Performing a magical ritual with the crucifix will allow Valek to not be afraid of sunlight and make him all-powerful. Vampire hunters must hurry, while Valek is still vulnerable, while he can still be killed....