The four survivors of the Woodsboro massacre - the Carpenter sisters and twins Chad and Mindy - have moved to New York City, where they are trying to start their lives over. Sam sees a therapist and, to Tara's displeasure, chafes at her every move, but as it soon becomes clear, for good reason. The masked maniac Ghostface starts killing again, and as Mindy suggests, neither new acquaintances nor old friends should be ruled out as suspects.