In "Teenage Mutant Ninja Turtles: Mutant Mayhem," the iconic turtles—Leonardo, Michelangelo, Donatello, and Raphael—spring into action once again. When their arch-nemesis, the Shredder, teams up with a nefarious scientist, the city faces a new level of peril. The turtles, alongside their intrepid allies April O'Neil and Casey Jones, must confront mutated foes and navigate dangerous challenges to save New York. Packed with martial arts, humor, and pizza-fueled camaraderie, the heroes in a half shell take on a mutant-infested mayhem to preserve peace.