
As a child, Peter Parker was abandoned by his parents, and so was brought up by his uncle and aunt. As the years went by, Peter was an ordinary model schoolboy, was attacked by bullies and was in love with his classmate Gwen Stacy, who secretly reciprocated his feelings. But after being bitten by a genetically altered spider, Peter gains incredible superpowers and his life changes forever.
However, he can't stop wondering what happened to his parents. He meets his father's longtime friend and partner, geneticist Kurt Connors, who was working with Peter's father to develop a regeneration formula. Peter helps to finish it, and Connors, who has wanted to regenerate his right arm all his life, injects the formula into himself and becomes a Lizard. Realizing his guilt, Peter begins a new life as the mysterious superhero Spider-Man and becomes a menace to criminals while trying to find a way to stop Connors.