With cunning and considerable skill, having obtained a priceless map of the upper reaches of the Amazon, the perky archaeologist Lily Houghton sets off on an expedition to find a magic tree, the flower of which - according to legend - has incredible healing properties. Taking her younger brother with her, who is not excited about the prospect of a trip into the wild jungle, the girl hires a guide - the captain of a cruise ship named Frank. The whole company embarks on an adventure, where they encounter not only deadly representatives of the Amazonian flora and fauna, but also traps set up by members of a rival expedition.